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Frontiers in Veterinary Science, a Scopus, PubMed and DOAJ indexed Quartile 1 journal with an impact factor of 3.2, published the following paper of the staff members of the FGBI “ARRIAH” (Vladimir), co-authored with colleagues from the National Research Centre “Kurchatov Institute” and the Moscow Institute of Physics and Technology:
Sharko F. S., Mazloum A., Krotova A. O., Byadovskaya O. P., Prokhvatilova L. B., Chvala I. A., Zolotikov U. E., Kozlova A. D., Krylova A. S., Grosfeld E. V., Prokopenko A. V., Korzhenkov A. A., Patrushev M. V., Namsaraev Z. B., Sprygin A. V., Toshchakov S. V. Metagenomic profiling of viral and microbial communities from the pox lesions of lumpy skin disease virus and sheeppox virus-infected hosts. Frontiers in Veterinary Science. 2024; 11:1321202. DOI: 10.3389/fvets.2024.1321202

The paper presents the results of metagenomic analysis of microbiome of skin scabs collected from animals (Bos taurus and Ovis aries) infected with lumpy skin disease virus and sheep pox virus. The samples were submitted from different regions of Russia for diagnosis confirmation using molecular biological methods.

The analysis revealed a high degree of variability in bacterial community structures across the affected skin samples, which is indicative of the importance of commensal microorganisms colonizing individual hosts. The most common bacteria detected in the skin lesion samples were Fusobacterium necrophorum, Streptococcus dysgalactiae, Helcococcus ovis and Trueperella pyogenes, irrespective of the host. Bacterial strains belonging to the genera Moraxella, Mannheimia, Corynebacterium, Staphylococcus and Micrococcus were identified.

The results of the study suggest that the skin lesions develop an active inflammatory process due to opportunistic microorganisms. This finding supports the rationale for implementing supplementary antibiotic treatment in cases of capripoxvirus infection.

The findings will provide a basis for further investigation into capripoxvirus infection pathogenesis.
The full text of the paper is available at https://doi.org/10.3389/fvets.2024.1321202